Kirkland Signature Glucosamine HCL 1500mg with MSM 1500mg, 375 TabletsED. 11 2027 Glucosamine and MSM is an effective supplement combination that helps support maximum flexibility, range of motion, joint lubrication and maintenance for healthy cartilage and connective tissue. Glucosamine is a basic building block for cartilage, synovial fluid and other connective tissues, which are needed for healthy structure integrity, and function of joints and optimum mobility. MSM (Methylsulfonylmethane) is a bioavailable sulfur.