SAM-eSAMe (S adenosyl L methionine) is a molecule that is naturally formed in the body. SAMe is a methyl donor in a process essential to normal cell health and function known as methylation. The methylation process can decline with age or as a result of chronic alcohol consumption, and it can be limited by genetic defects.* SAMe contributes to the synthesis, activation, and metabolism of neurotransmitters, proteins, nucleic acids, phospholipids, hormones,