IS Clinical Active Serum-1ozAge Defying, Clearing Brightening Description: iS Clinical Active Serum decreases the appearance of fine lines and wrinkles, visibly evens skin tone, and is excellent for blemish prone skin. Potent activity will be noted upon application as evidenced by a cool tingling sensation. Excellent for all skin types and all ages, this powerful botanical serum leaves the skin moist and smooth. Benefits: Reduces the appearance of fine lines and wrinkles