GA231000: Fmoc-Thr(GlcNAc(Ac)3-β-D)-OHO GlcNAc on proteins plays fundamental roles as a cellular nutrient and stress sensor and thus central in the etiologies of chronic diseases of aging, including diabetes, cancer and neurodegenerative disease. In dynamic protein glycosylation, reversible O GlcNAc modification of nuclear and cytoplasmic proteins at serine and threonine controls diverse aspects of cell physiology and is conceptually analogous to phosphorylation. 160168 40 1 O GlcNAc